Inhibition of preadipocyte proliferation by mitochondrial reactive oxygen species
نویسندگان
چکیده
منابع مشابه
Mitochondrial metabolism of reactive oxygen species.
For a long time mitochondria have mainly been considered for their role in the aerobic energy production in eukaryotic cells, being the sites of the oxidative phosphorylation, which couples the electron transfer from respiratory substrates to oxygen with the ATP synthesis. Subsequently, it was showed that electron transfer along mitochondrial respiratory chain also leads to the formation of rad...
متن کاملControl of cell proliferation by reactive oxygen species.
In 1989 my colleague and I reported that low concentrations of 0;' or H202 stimulated proliferation when added to cultures of BHK-21 hamster fibroblasts [ 11. A considerable variety of non-inflammatory mammalian cells exhibit positive growth responses when exposed to low levels of exogenous 0;' or H202 [2]. In our studies, whereas H202 stimulated the growth of both non-transformed and polyoma-v...
متن کاملMitochondrial Cardiomyopathy Caused by Elevated Reactive Oxygen Species and Impaired Cardiomyocyte Proliferation.
RATIONALE Although mitochondrial diseases often cause abnormal myocardial development, the mechanisms by which mitochondria influence heart growth and function are poorly understood. OBJECTIVE To investigate these disease mechanisms, we studied a genetic model of mitochondrial dysfunction caused by inactivation of Tfam (transcription factor A, mitochondrial), a nuclear-encoded gene that is es...
متن کاملMitochondrial reactive oxygen species and Ca signaling
Camello-Almaraz, Cristina, Pedro J. Gomez-Pinilla, Maria J. Pozo, and Pedro J. Camello. Mitochondrial reactive oxygen species and Ca signaling. Am J Physiol Cell Physiol 291: C1082–C1088, 2006; doi:10.1152/ajpcell.00217.2006.—Mitochondria are an important source of reactive oxygen species (ROS) formed as a side product of oxidative phosphorylation. The main sites of oxidant production are compl...
متن کاملMitochondrial reactive oxygen species and Ca2+ signaling.
Mitochondria are an important source of reactive oxygen species (ROS) formed as a side product of oxidative phosphorylation. The main sites of oxidant production are complex I and complex III, where electrons flowing from reduced substrates are occasionally transferred to oxygen to form superoxide anion and derived products. These highly reactive compounds have a well-known role in pathological...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 2003
ISSN: 0014-5793
DOI: 10.1016/s0014-5793(03)00862-7